Endocrine Abstracts

Introduction: Emphysematous pyelonephritis(EPN) is a necrotizing infection of the renal parenchyma. Most cases occur in the setting of uncontrolled diabetes mellitus(DM). Presentation ranges from mild symptoms to shock and altered sensorium.Objective: To highlight efficacy of intensive, appropriate medical therapy in management of a rare but life-threatening infection.Case presentation: A 54-year old man presented with 3 week histo...

Introduction: Turner Syndrome (TS) is the most common chromosomal abnormality affecting phenotypic females. Short stature (SS) is one of the most consistent clinical features of TS, with consequent poor psychosocial outcomes. Management involves early diagnosis and administration of recombinant human growth hormone (rhGH). The cost of therapy however hampers treatment in resource-challenged regions. The objective of this presentation is to report the outcome and challenges of ...

Introduction: Hypopituitarism refers to deficiency of one or more of the pituitary hormones. Hypopituitarism is often partial, thus replacement is individualized. Hormonal replacement improves quality of life in these patients.Objective: To describe the demographic characteristics and patterns of hormonal replacement in patients with hypopituitarism attending the Endocrinology clinic of a tertiary hospital in Lagos, Nigeria.Methods...

Introduction: Primary hyperparathyroidism is a common endocrine disorder. Symptoms at onset are often non-specific, thus the diagnosis tends to be overlooked.Objective: To highlight varying modes of presentation in primary hyperparathyroidism, the need for early recognition and treatment to prevent complications.Case Presentation: A 51-year old woman presented with complaints of back and lower limb pains of 7-year duration. She als...

Background: Severe hypocalcaemia is a life threatening metabolic emergency which must be identified and treated properly to prevent mortality.Objective: To highlight a rare finding of severe hypocalcaemia due to hypovitaminosis D in a Nigerian female on anti-tuberculous therapy.Case presentation: A 30-year-old Nigerian female who wears purdah presented to the medical emergency on account of perioral numbness, generalised muscle spa...

Introduction: Major risk factors for cardiovascular disease and outcome include, though not limited to, hypertension, diabetes mellitus and obesity. In the wake of present urbanization, the prevalence of these risk factors has increased, impacting greatly on disease burden.Objectives: To determine the prevalence of undiagnosed Diabetes, Hypertension, Obesity and associated demographic factors in a market population in La...

Introduction: Functional Hypogonadism (FH) is a condition with low circulating serum testosterone and an intact Hypothalmo-pituitary-gonadal axis. The use of testosterone replacement therapy (TRT) use in FH is controversial based on the risk-benefit ratio. This report highlights the benefits of managing FH with TRT. Case Presentation: 47-year-old man presented to the endocrine clinic on account of poor erection, reductio...

Background: One of the rarely documented endocrine disorders in African setting is pseudo-haemaphroditism. Female pseudo-haemaphroditism (virilized female) is characterized by the presence of 46XX karyotype, ovaries, normal mullerian duct structures, absent wolffian duct structures and virilised genitalia due to androgens in-utero. The commonest cause is Congenital Adrenal Hyperplasia.Aim: To highlight the challenge in investig...

Background: One of the rarely documented endocrine disorders in African setting is pseudo-haemaphroditism. Female pseudo-haemaphroditism (virilized female) is characterized by the presence of 46XX karyotype, ovaries, normal mullerian duct structures, absent wolffian duct structures and virilised genitalia due to androgens in-utero. The commonest cause is Congenital Adrenal Hyperplasia.Aim: To highlight the challenge in investig...

Background: Gestational diabetes mellitus (GDM) is defined as glucose intolerance resulting in hyperglycaemia of variable severity, with onset or first recognition during pregnancy. GDM is a risk factor for dysglycaemia in later life. The objective of the study was to determine the impact of GDM on glucose tolerance in the short term post-delivery in a cohort of women who attended the Lagos University Teaching Hospital (LUTH)Study Design: This was a pros...